Correlative imaging study in the diagnosis of ovarian cancer recurrences
Identifieur interne : 000337 ( Main/Exploration ); précédent : 000336; suivant : 000338Correlative imaging study in the diagnosis of ovarian cancer recurrences
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Abstract
A correlative imaging study was carried out in 61 female patients previously treated for ovarian carcinoma. Upon suspicion of recurrence, abdominopelvic immunoscintigraphy (IS) using F(ab′)2 fragments of indium-111-labelled OC 125 monoclonal antibody was performed in all patients, Ultrasonography (US) and computed tomography (CT) were performed 53 and 37 times, respectively. The diagnostic accuracy of the different imaging techniques was studied per site (abdomen and pelvis) and per patient. The diagnostic accuracy of planar scintigraphy (PS) was slightly lower than that of emission computed tomography (ECT): 66% vs 73% for abdomen, 65% vs 72% for pelvis, and 78% vs 84% in analysis per patient. The accuracy of IS (PS and ECT combined) was markedly better than that of US and CT for abdomen (IS=73%; US=30%; CT=47%), pelvis (IS=73%; US=37%; CT=52%) and analysis per patient (IS=85%; US=43%; CT =59%). The results of IS and morphological imaging techniques (MIT: US and/or CT) were correlatively analysed with the frequency of recurrence. When IS and MIT were both negative, the frequency of non-recurrence was 14/23 for abdomen, 7/12 for pelvis and 8/13 in analysis per patient. On the other hand, when both IS and MIT were positive, the frequency of recurrence was high (9/9 for abdomen, 17/21 for pelvis and 24/26 for analysis per patient). It was also found that a positive IS associated with a negative MIT was still highly suggestive of recurrence (17/21 for abdomen, 16/22 for pelvis and 17/19 for analysis per patient). The results of this study strongly suggest that 111in-labelled OC 125 IS is accurate for the diagnosis of recurrence of ovarian cancer and provides complementary data to those obtained by MIT.
DOI: 10.1007/BF00180860
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Upon suspicion of recurrence, abdominopelvic immunoscintigraphy (IS) using F(ab′)2 fragments of indium-111-labelled OC 125 monoclonal antibody was performed in all patients, Ultrasonography (US) and computed tomography (CT) were performed 53 and 37 times, respectively. The diagnostic accuracy of the different imaging techniques was studied per site (abdomen and pelvis) and per patient. The diagnostic accuracy of planar scintigraphy (PS) was slightly lower than that of emission computed tomography (ECT): 66% vs 73% for abdomen, 65% vs 72% for pelvis, and 78% vs 84% in analysis per patient. The accuracy of IS (PS and ECT combined) was markedly better than that of US and CT for abdomen (IS=73%; US=30%; CT=47%), pelvis (IS=73%; US=37%; CT=52%) and analysis per patient (IS=85%; US=43%; CT =59%). The results of IS and morphological imaging techniques (MIT: US and/or CT) were correlatively analysed with the frequency of recurrence. When IS and MIT were both negative, the frequency of non-recurrence was 14/23 for abdomen, 7/12 for pelvis and 8/13 in analysis per patient. On the other hand, when both IS and MIT were positive, the frequency of recurrence was high (9/9 for abdomen, 17/21 for pelvis and 24/26 for analysis per patient). It was also found that a positive IS associated with a negative MIT was still highly suggestive of recurrence (17/21 for abdomen, 16/22 for pelvis and 17/19 for analysis per patient). The results of this study strongly suggest that 111in-labelled OC 125 IS is accurate for the diagnosis of recurrence of ovarian cancer and provides complementary data to those obtained by MIT.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="1374ae5322dbc2f13b7e57ae9c4b439009392abe"><titleInfo lang="eng"><title>Correlative imaging study in the diagnosis of ovarian cancer recurrences</title></titleInfo><name type="personal"><namePart type="given">Patrick</namePart><namePart type="family">Peltier</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Service de Médecine Nucléaire, Centre René Gauducheau, Nantes, France</affiliation></name><name type="personal"><namePart type="given">Kunto</namePart><namePart type="family">Wiharto</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Service de Médecine Nucléaire, Centre René Gauducheau, Nantes, France</affiliation></name><name type="personal"><namePart type="given">Jean-Philippe</namePart><namePart type="family">Dutin</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Service de Médecine Nucléaire, Centre René Gauducheau, Nantes, France</affiliation></name><name type="personal"><namePart type="given">Jean-François</namePart><namePart type="family">Chatal</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Service de Médecine Nucléaire, Centre René Gauducheau, Nantes, France</affiliation></name><name type="personal"><namePart type="given">Patrick</namePart><namePart type="family">Bourguet</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Service de Médecine Nucléaire, Centre Eugène Marquis, Rennes, France</affiliation></name><name type="personal"><namePart type="given">Jean-Claude</namePart><namePart type="family">Liehn</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Service de Médecine Nucléaire, Institut Jean Godinot, Reims, France</affiliation></name><name type="personal"><namePart type="given">Jean-Philippe</namePart><namePart type="family">Vuillez</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Service de Médecine Nucléaire, Hôpital Albert Michalon, Grenoble, France</affiliation></name><name type="personal"><namePart type="given">Jean-Yves</namePart><namePart type="family">Hérry</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Service de Médecine Nucléaire, Centre Eugène Marquis, Rennes, France</affiliation></name><name type="personal"><namePart type="given">Andréas</namePart><namePart type="family">Loboguerrero</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Service de Médecine Nucléaire, Institut Jean Godinot, Reims, France</affiliation></name><typeOfResource>text</typeOfResource><genre>Original Article</genre><genre>Original Paper</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1992-04-15</dateCreated><dateValid encoding="w3cdtf">2004-07-07</dateValid><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">A correlative imaging study was carried out in 61 female patients previously treated for ovarian carcinoma. Upon suspicion of recurrence, abdominopelvic immunoscintigraphy (IS) using F(ab′)2 fragments of indium-111-labelled OC 125 monoclonal antibody was performed in all patients, Ultrasonography (US) and computed tomography (CT) were performed 53 and 37 times, respectively. The diagnostic accuracy of the different imaging techniques was studied per site (abdomen and pelvis) and per patient. The diagnostic accuracy of planar scintigraphy (PS) was slightly lower than that of emission computed tomography (ECT): 66% vs 73% for abdomen, 65% vs 72% for pelvis, and 78% vs 84% in analysis per patient. The accuracy of IS (PS and ECT combined) was markedly better than that of US and CT for abdomen (IS=73%; US=30%; CT=47%), pelvis (IS=73%; US=37%; CT=52%) and analysis per patient (IS=85%; US=43%; CT =59%). The results of IS and morphological imaging techniques (MIT: US and/or CT) were correlatively analysed with the frequency of recurrence. When IS and MIT were both negative, the frequency of non-recurrence was 14/23 for abdomen, 7/12 for pelvis and 8/13 in analysis per patient. On the other hand, when both IS and MIT were positive, the frequency of recurrence was high (9/9 for abdomen, 17/21 for pelvis and 24/26 for analysis per patient). It was also found that a positive IS associated with a negative MIT was still highly suggestive of recurrence (17/21 for abdomen, 16/22 for pelvis and 17/19 for analysis per patient). The results of this study strongly suggest that 111in-labelled OC 125 IS is accurate for the diagnosis of recurrence of ovarian cancer and provides complementary data to those obtained by MIT.</abstract><subject lang="eng"><genre>Key words</genre><topic>OC 125 monoclonal antibody</topic><topic>Immunoscintigraphy</topic><topic>Ovarian cancer</topic><topic>Diagnosis of recurrence</topic><topic>Correlative imaging</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Eur J Nucl Med</title></titleInfo><titleInfo><title>European Journal of Nuclear Medicine</title><partNumber>Year: 1992</partNumber><partNumber>Volume: 19</partNumber><partNumber>Number: 12</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1992-12-01</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Imaging / Radiology</topic><topic>Nuclear Medicine</topic></subject><identifier type="issn">0340-6997</identifier><identifier type="issn">Electronic: 1619-7089</identifier><identifier type="matrixNumber">259</identifier><identifier type="local">IssueArticleCount: 13</identifier><recordInfo><recordOrigin>Springer-Verlag Berlin Heidelberg, 1992</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF00180860</identifier><identifier type="matrixNumber">Art3</identifier><identifier type="local">BF00180860</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>1006</start><end>1010</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1992</recordOrigin><recordIdentifier>259_1992_Article_BF00180860.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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